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盐酸托莫西汀

Atomoxetine HCl （订货以英文为准）

编号：A129721
CAS号：82248-59-7
分子式：C17H21NO.HCL
分子量：291.82
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A129721-1g 阿拉丁 1g ¥136.90
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A129721-50mg 阿拉丁 50mg ¥29.90
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A129721-250mg 阿拉丁 250mg ¥41.90
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A129721-5g 阿拉丁 5g ¥579.90
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A129721-25g 阿拉丁 25g ¥2056.90
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产品名称 Atomoxetine HCl
中文名称 盐酸托莫西汀
CAS号 82248-59-7
分子式（M.F.） C17H21NO.HCL
分子量（M.W.） 291.82
储存条件 -20°C储存
敏感性对热和湿度敏感
溶解性DMSO 58 mg/mL Water 2 mg/mL Ethanol 37 mg/mL
存贮条件储存温度-20°C
应用A selective SLC6A2 inhibitor.
产品介绍Atomoxetine HCl是一种选择性的去甲肾上腺素(NE)转运体抑制剂，Ki为5 nM，作用于人体5-HT和DA转运体亲和力比其低15和290倍。
备注Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.Phase 4.
生化机理Tomoxetine hydrochloride (Atomoxetine, LY 139603) is a competitive and specific inhibitor of SLC6A2 while demonstrating weak ST and DAT inhibition as studied in synaptosomes of rat hypothalamus. Additionally, studies indicate that this (-) optical isomer is more effective than the (+) isomer, LY139602 (ent S-(+)-Atomoxetine Hydrochloride;). In the prefrontal cortex of rats, Tomoxetine was reported to not cause an increase in dopamine within the striatum or nucleus accumbens which may be useful in additional research studies investigating the reward pathways of the brain. Tomoxetine hydrochloride is an inhibitor of NMDA.
别名盐酸托莫西汀;盐酸阿托莫西汀; (R)-N-甲基-3-(2-甲基苯氧基)-3-苯丙基胺盐酸盐;(R)-Tomoxetine Hydrochloride;(R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropylamine Hydrochloride; LY 139603
标识符号https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词Warning
危害声明H302
个人防护设备dust mask type N95 (US), Eyeshields, Gloves
RTECSMU6640000
WGK德国3
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