溶解性 | Soluble in DMSO (40 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
存贮条件 | 储存温度-20°C |
应用 | A potent inhibitor of EGFR phosphorylation. |
产品介绍 | AZD8931 (Sapitinib)是一种可逆的,ATP竞争性EGFR, ErbB2和ErbB3抑制剂,IC50分别为4 nM, 3 nM和4 nM,作用于NSCLC细胞比Gefitinib或Lapatinib更有效,作用于ErbB家族比作用于MNK1和Flt选择性强100倍。 |
备注 | AZD8931 is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and |
生化机理 | AZD8931 is an ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3 (the IC50 values are 4 nM, 3 nM and 4 nM, respectively). |
别名 | 4-(3-氯-2-氟苯胺基)-7-甲氧基-6-[[1-(N-甲基氨基甲酰甲基)哌啶-4-基]氧基]喹唑啉;AZD 8931;4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline; AZD 8931;Sapitinib |
沙匹替尼
AZD8931 (Sapitinib) (订货以英文为准)
编号:A129380
CAS号:848942-61-0
分子式:C23H25CLFN5O3
分子量:473.93
产品名称 | AZD8931 (Sapitinib) |
中文名称 | 沙匹替尼 |
CAS号 | 848942-61-0 |
分子式(M.F.) | C23H25CLFN5O3 |
分子量(M.W.) | 473.93 |
储存条件 | -20°C储存 |
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