| 溶解性 | Soluble in DMSO (124 mg/mL), water (<1 mg/mL), and ethanol (<1 mg/mL). |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A potent and selective inhibitor of EGFR phosphorylation. |
| 产品介绍 | AST-1306 TsOH是一种新型，不可逆的EGFR和ErbB2抑制剂，IC50分别为0.5 nM和3 nM，对突变型EGFR T790M/L858R也有效，作用于过表达ErbB2的细胞更有效，作用于ErbB家族比作用于其他激酶选择性高3000倍。 |
| 备注 | AST-1306 TsOH is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases, |
| 生化机理 | AST-1306 TsOH is a potent(pM) and selective inhibitor of EGFR and ErbB4 (IC50 = 500pM and 800 pM, respectively). AST 1306 blocks phosphorylation of EGFR and also prevents downstream pathways. AST 1306 also dose-dependently inhibits EGF-induced EGFR phosphorylation in the A549 cancer cell line. |
| 别名 | N-[4-[[3-氯-4-[(3-氟苯基)甲氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯酰胺对甲苯磺酸盐;N-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide 4-methylbenzenesulfonate;AST-1306 (p-Toluenesulfonic acid); AST1306 (p-Toluenesulfonic acid); AST 1306 (p-Toluenesulfonic acid;AST-6 |
N-[4-[[3-氯-4-[(3-氟苯基)甲氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯酰胺对甲苯磺酸盐
AST-1306 TsOH （订货以英文为准）
编号：A129426
CAS号：1050500-29-2
分子式：C24H18CLFN4O2.C7H8O3S
分子量：621.08
| 产品名称 | AST-1306 TsOH |
| 中文名称 | N-[4-[[3-氯-4-[(3-氟苯基)甲氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯酰胺对甲苯磺酸盐 |
| CAS号 | 1050500-29-2 |
| 分子式（M.F.） | C24H18CLFN4O2.C7H8O3S |
| 分子量（M.W.） | 621.08 |
| 储存条件 | 2-8°C储存 |
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