| 熔点 | 212°C |
| 旋光率 | -175.5 ° (C=1, EtOH) |
| 溶解性 | Soluble in ethanol (~20 mg/ml), dimethyl formamide (~20 mg/ml), DMSO (~20 mg/ml), water (>5 mg/ml), DMF, PBS pH 7.2, and Methanol. |
| 存贮条件 | 储存温度 2-8°C |
| 密度 | 1.9000 |
| 应用 | An inhibitor of Bcl-2 and NOS2 |
| 产品介绍 | (-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS). |
| 生化机理 | (-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, with broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDL) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. After treating with EGCG, the expressions of HES1 and Notch2 was obviously inhibited, this indicated that EGCG inhibited colorectal cancer by inhibiting HES1 and Notch2. |
| 别名 | (-)-顺式-2-(3,4,5-三羟基苯基)-3,4-二氢-1(2H)-苯并吡喃-3,5,7--三醇;3-没食子酸酯;(-)-顺式-3,3′,4′,5,5′,7-六羟基-黄烷-3-没食子酸酯;EGCG;(-)-cis-3,3′,4′,5,5′,7-Hexahydroxy-flavane-3-gallate;(-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate;(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate);Teavigo;Tea catechin;EGCG |
(-)-表没食子儿茶素没食子酸酯
(-)-Epigallocatechin gallate （订货以英文为准）
编号：E107404
CAS号：989-51-5
分子式：C22H18O11
分子量：458.37
| 产品名称 | (-)-Epigallocatechin gallate |
| 中文名称 | (-)-表没食子儿茶素没食子酸酯 |
| CAS号 | 989-51-5 |
| 分子式（M.F.） | C22H18O11 |
| 分子量（M.W.） | 458.37 |
| 储存条件 | 2-8°C储存 |
| Merck Index | 3074 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs06.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H301,H312,H350 |
| 警示性声明 | P201,P280,P301+P310,P308+P313 |
| 个人防护设备 | Eyeshields,Faceshields,full-face respirator (US),Gloves,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter |
| RTECS | UB1400000 |
| WGK德国 | 3 |
| 闪点（摄氏） | 85℃ |
| 风险声明 (欧洲) | R21;R25;R45 |
| 安全声明（欧洲） | S45;S53 |
| 危害码（欧洲） | T |
| 是否危化品 | 一般危化品 |
| UN代码 | 2750 |
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