| 熔点 | >275℃ |
| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in water. |
| 存贮条件 | 储存温度-20°C |
| 应用 | Carboplatin has been used:· in chemotherapy-induced thrombocytopenia mouse model and treatment· to induce cell death in a large subset of colorectal cancer cells· in the evaluation of cell proliferation and chemosensitivity· as a positive control for suppressed cell growth |
| 产品介绍 | Carboplatin is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of carboplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of antineoplastic agents. The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules, including enzymes, which might play a role in their mechanism of action. |
| 生化机理 | Carboplatin damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death. |
| 别名 | 卡波铂; 碳铂; 顺-二氨-1,1-环丁烷基二羟酸铂; 顺-二氨-1,1-环丁烷基二羧酸铂; 顺式-1,1-环丁烷二羧酸二氨铂;cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II); cis-Diammine(1,1-cyclobutanedicarboxylato) platinum;1,1-Cyclobutanedicarboxylatodiammineplatinum(II); cis-Diammine(1,1-cyclobutanedicarboxylato) platinum ; |
卡铂
Carboplatin （订货以英文为准）
编号：C110682
CAS号：41575-94-4
分子式：C6H12N2O4PT
分子量：371.25
| 产品名称 | Carboplatin |
| 中文名称 | 卡铂 |
| CAS号 | 41575-94-4 |
| 分子式（M.F.） | C6H12N2O4PT |
| 分子量（M.W.） | 371.25 |
| 储存条件 | 避光;-20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs05.jpg,https://www.aladdin-e.com/images/ghs/ghs06.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H301,H315,H317,H318,H334 |
| 警示性声明 | P261,P280,P301+P310,P305+P351+P338,P342+P311 |
| 个人防护设备 | Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges |
| RTECS | TP1850000 |
| WGK德国 | 1 |
| 风险声明 (欧洲) | R25;R38;R41;R42/43; |
| 安全声明（欧洲） | S22;S26;S36/37/39/;S45; |
| 危害码（欧洲） | T |
| UN代码 | 3288 |
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