熔点 | 200-203°C |
存贮条件 | 储存温度-20°C |
密度 | 1.2780 |
应用 | cAMP 和 cGMP 磷酸二脂酶的非专一性抑制剂。IBMX抑制了磷酸二脂酶,cAMP的增加激活了PKA ,其结果是减少增殖,增加分化和诱发凋亡. IBMX抑制由苯肾上腺素诱导的色胺(来自于神经内分泌上皮细胞的减少粘液IC50: 1.3 μM)的减少 。也作为腺苷受体拮抗剂。 |
产品介绍 | IBMX is a widely-used non-specific inhibitor of cyclic AMP (cAMP) and cyclic GMP (cGMP) phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors,typically antagonizing the suppressive effects of natural agonists. |
别名 | IBMX;1-甲基-3-异丁基黄嘌呤;3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮;3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮;3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮;1-Methyl-3-isobutylxanthine3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione3-Isobutyl-1-methyl-2,6(1H,3H)-purinedioneIBMXMIX |
3-异丁基-1-甲基黄嘌呤(IBMX)
3-Isobutyl-1-methylxanthine (订货以英文为准)
编号:I106812
CAS号:28822-58-4
分子式:C10H14N4O2
分子量:222.24
产品名称 | 3-Isobutyl-1-methylxanthine |
中文名称 | 3-异丁基-1-甲基黄嘌呤(IBMX) |
CAS号 | 28822-58-4 |
MDL编码 | MFCD00005584 |
分子式(M.F.) | C10H14N4O2 |
分子量(M.W.) | 222.24 |
储存条件 | -20°C储存 |
Reaxys-RN | 166004 |
个人防护设备 | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
WGK德国 | 3 |
搜索质检报告(COA)
搜索MSDS
相关产品