溶解性 | DMSO : 50 mg/mL (174.97 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) |
存贮条件 | 储存温度-20°C |
产品介绍 | Asenapine(Org 5222)能抑制肾上腺素受体,对α1,α2A,α2B和α2C的Ki为0.25-1.2 nM,还能抑制 5-HT受体,对1A,1B,2A,2B,2C,5A,6和7的Ki为0.03-4.0 nM。 |
生化机理 | Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors. Asenapine behaves as an antagonist at all receptors. |
别名 | 阿塞那平; 反式-5-氯-2,3,3a,12b-四氢-2-甲基-1H-二苯并[2,3:6,7]氧杂卓并[4,5-c]吡咯;Saphris;Org 5222;Org-5222;Org5222; trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole |
阿塞那平
Asenapine (订货以英文为准)
编号:A127318
CAS号:65576-45-6
分子式:C17H16CLNO
分子量:285.77
产品名称 | Asenapine |
中文名称 | 阿塞那平 |
CAS号 | 65576-45-6 |
分子式(M.F.) | C17H16CLNO |
分子量(M.W.) | 285.77 |
储存条件 | -20°C储存 |
标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
信号词 | Warning |
危害声明 | H317-H319 |
警示性声明 | P280-P305 + P351 + P338 |
WGK德国 | 3 |
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