S3I-201,STAT3抑制剂

S3I-201 (订货以英文为准)

编号:S129625
CAS号:501919-59-1
分子式:C16H15NO7S
分子量:365.36
货号 品牌 包装 目录价 您的价格 库存 数量 购买
S129625-10mg 阿拉丁 10mg ¥428.90
S129625-5mg 阿拉丁 5mg ¥267.90
S129625-50mg 阿拉丁 50mg ¥1400.90
S129625-100mg 阿拉丁 100mg ¥1956.90
S129625-25mg 阿拉丁 25mg ¥834.90
产品名称 S3I-201
中文名称 S3I-201,STAT3抑制剂
CAS号 501919-59-1
分子式(M.F.) C16H15NO7S
分子量(M.W.) 365.36
储存条件 -20°C储存;充氩
溶解性DMSO 73 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
产品介绍S3I-201
备注S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM, and low activity towards STAT1 and STAT5.
生化机理NSC 74859 (S3I-201) inhibits Stat3-Stat3 complex formation and Stat3 DNA-binding (IC50 =86 ±33μM) and transcriptional activities. Furthermore, S31-201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated Stat3. NSC 74859 (S3I-201) inhibits the expression of the Stat3-regulated genes encoding cyclin D1, BcI-xL, and survivin and inhibits the growth of human breast tumors in vivo. Therefore the antitumor activity of S31-201 is mediated in part through inhibition of aberrant Stat3 activation and provide the proof-of-concept for the potential clinical use of Stat3 inhibitors such as NSC 74859 (S31-201) in tumors harboring aberrant Stat3.
别名2-hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid;2-hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid
标识符号https://www.aladdin-e.com/images/ghs/ghs05.jpg
信号词Danger
危害声明H318
警示性声明P280-P305 + P351 + P338
个人防护设备dust mask type N95 (US), Eyeshields, Gloves
RTECSUS7975550
WGK德国3
搜索质检报告(COA)
搜索MSDS
相关产品
CAS号:7704-98-5
¥ 419.00 T819979-100g
CAS号:7758-02-3
¥ 223.00 P816703-25g
CAS号:288-32-4
¥ 60.00 I811843-25g
CAS号:7791-20-0
¥ 899.00 N814991-5g
CAS号:71-41-0
¥ 115.00 P815993-500ml
CAS号:108-46-3
¥ 225.00 R817303-100g
CAS号:1499-10-1
¥ 556.00 D807000-250mg
CAS号:98-88-4
¥ 258.00 B802234-500g
CAS号:9002-92-0
¥ 520.00 767315-5g