| 敏感性 | 对热、光线敏感 |
| 溶解性 | DMSO 100 mg/mL Water 100 mg/mL Ethanol 100 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Aliskiren Hemifumarate是一种直接肾素抑制剂，IC50为1.5 nM。 |
| 备注 | Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM. |
| 生化机理 | Aliskiren hemifumarate is a hemifumarate salt form of Aliskiren. Aliskiren is a direct renin inhibitor with an IC50 of 0.72?nM against renin. Renin is the first enzyme in the renin-angiotensin-aldosterone system which plays a role in blood pressure control. Renin cleaves angiotensinogen to angiotensin I, which is in turn converted by (ACE) to angiotensin II. Angiotensin II has both direct and indirect effects on blood pressure. It directly causes arterial smooth muscle to contract, leading to vasoconstriction and increased blood pressure. Angiotensin II also stimulates the production of aldosterone from the adrenal cortex, which causes the tubules of the kidneys to increase reabsorption of sodium, with water following thereby increasing plasma volume and blood pressure. Aliskiren binds to the S3bp binding pocket of renin, essential for its activity. Binding to this pocket prevents the conversion of angiotensinogen to angiotensin I. Aliskiren is also available as combin |
| 别名 | 阿利克仑半富马酸盐; (2S,4S,5S,7S)-5-氨基-N-(2-氨基甲酰基-2-甲基丙基)-4-羟基-2-异丙基-7-[4-甲氧基-3-(3-甲氧基丙氧基)苄基]-8-甲基壬酰胺半富马酸盐; |
阿利吉仑半富马酸盐
Aliskiren Hemifumarate （订货以英文为准）
编号：A129231
CAS号：173334-58-2
分子式：C30H53N3O6.1/2C4H4O4
分子量：609.83
| 产品名称 | Aliskiren Hemifumarate |
| 中文名称 | 阿利吉仑半富马酸盐 |
| CAS号 | 173334-58-2 |
| 分子式（M.F.） | C30H53N3O6.1/2C4H4O4 |
| 分子量（M.W.） | 609.83 |
| 储存条件 | -20°C储存 |
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