| 熔点 | 215°C |
| 溶解性 | DMSO ≥57mg/mL Water <1.2mg/mL Ethanol ≥8mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells |
| 产品介绍 | AG-490 (Tyrphostin AG 490)是EGFR抑制剂，IC50为100nM，比对ErbB2的抑制性高135倍，对Lck，Lyn，Btk，Syk和Src无活性。 |
| 备注 | AG-490 (Tyrphostin B42) is an inhibitor of EGFR with IC50 of 0.1 μM, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src. |
| 生化机理 | AG-490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo. |
| 别名 | 酪氨酸激酶抑制剂AG 490;(E)-N-苯甲基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺;AG 490;Tyrphostin AG 490;AG490; tyrphostin ag 490;ag 490; (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide;2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
酪氨酸激酶抑制剂AG 490
AG-490 (Tyrphostin B42) （订货以英文为准）
编号：A126525
CAS号：133550-30-8
分子式：C17H14N2O3
分子量：294.30
| 产品名称 | AG-490 (Tyrphostin B42) |
| 中文名称 | 酪氨酸激酶抑制剂AG 490 |
| CAS号 | 133550-30-8 |
| 分子式（M.F.） | C17H14N2O3 |
| 分子量（M.W.） | 294.30 |
| 储存条件 | -20°C储存 |
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