| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 生化机理 | AST-1306 functions as an irreversible inhibitor, most likely through covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and ErbB2, respectively. Further studies showed that AST-1306 inactivated pathways downstream of these receptors and thereby inhibited the proliferation of a panel of cancer cell lines. AST-1306 is a potent(pM) and selective inhibitor of EGFR and ErbB4 (IC50 = 500pM and 800 pM, respectively). AST-1306 blocks phosphorylation of EGFR and also prevents downstream pathways. AST-1306 also dose-dependently inhibits EGF-induced EGFR phosphorylation in the A549 cancer cell line. |
艾力替尼
AST-1306 （订货以英文为准）
编号：A127889
CAS号：897383-62-9
分子式：C24H18CLFN4O2
分子量：448.88
| 产品名称 | AST-1306 |
| 中文名称 | 艾力替尼 |
| CAS号 | 897383-62-9 |
| 分子式（M.F.） | C24H18CLFN4O2 |
| 分子量（M.W.） | 448.88 |
| 储存条件 | -20°C储存 |
| 信号词 | Danger |
| 危害声明 | H301-H315-H319-H335-H413 |
| 警示性声明 | P261-P301 + P310-P305 + P351 + P338 |
| 个人防护设备 | dust mask type N95 (US)， Eyeshields， Faceshields， Gloves |
| WGK德国 | 3 |
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