克拉屈滨

Cladribine (订货以英文为准)

编号:C129833
CAS号:4291-63-8
分子式:C10H12CLN5O3
分子量:285.69
货号 品牌 包装 目录价 您的价格 库存 数量 购买
C129833-100mg 阿拉丁 100mg ¥229.90
C129833-10mg 阿拉丁 10mg ¥39.90
C129833-50mg 阿拉丁 50mg ¥149.90
C129833-250mg 阿拉丁 250mg ¥309.90
C129833-1g 阿拉丁 1g ¥799.90
产品名称 Cladribine
中文名称 克拉屈滨
CAS号 4291-63-8
MDL编码 MFCD00153939
分子式(M.F.) C10H12CLN5O3
分子量(M.W.) 285.69
储存条件 2-8°C储存
熔点220°C
敏感性对热敏感
溶解性Soluble in DMSO ( ≥57 mg/ml), water (<1 mg/ml), ethanol (<1 mg/ml), and methanol.
存贮条件储存温度2-8°C
应用It is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s).Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).
产品介绍Cladribine是一种腺苷脱氨酶抑制剂,作用于U266, RPMI8226,和MM1.S细胞,IC50分别约为2.43 μM, 0.75 μM,和0.18 μM。
备注Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.
生化机理2-Chloro-2'-deoxyadenosine is a deoxyadenosine analog that induces apoptosis in chronic lymphocytic leukemia (CLL) cells. Studies show that 2-chloro-2′-deoxyadenosine can be produced from intact cells of Escherichia coli that produce B-2194 thermostable purine-nucleoside phosphorylase II. In addition, in vitro studies show that 2-Chloro-2′-deoxyadenosine can inhibit human T and B cell lymphoproliferative responses possibly by inhibiting DNA repair. Furthermore, Staphylococcus aureus Cowan-induced expression of CD25 on B-cells is suppressed by 2-Chloro-2′-deoxyadenosine. 2-Chloro-2′-deoxyadenosine is an inhibitor of Adenosine deaminase.
别名CdA;克拉利宾;克拉屈滨;2-氯-2'-脱氧腺嘌呤核苷;2-氯-9-(2-脱氧-β-D-呋喃阿拉伯糖基)腺嘌呤;CdA;2CdA;CldAdo; Leustat; Leustatin; 2-Chloro-2'-deoxyadenosine;2-Chloro-9-(2-deoxy-β-D-arabinofuranosyl)adenine
搜索质检报告(COA)
搜索MSDS
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