| 溶解性 | Soluble in DMSO (61 mg/ml at 25 °C), ethanol (15 mg/ml) with warming, DMF (~5 mg/ml), water (<1 mg/ml at 25 °C), and methanol. |
| 存贮条件 | 储存温度-20°C |
| 应用 | An inhibitor of JAK1, JAK2, and JAK3. |
| 产品介绍 | Ruxolitinib (INCB018424)是第一个应用于临床的、有效的、选择性的JAK1/2抑制剂，IC50为3.3 nM/2.8 nM。作用于JAK1， JAK2与 作用于JAK3相比，选择性强130倍多。 |
| 备注 | INCB018424 is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3. |
| 生化机理 | Ruxolitinib (INCB018424) is a JAK inhibitor of JAK1 (IC50 = 2.7 nM), JAK2 (IC50 = 4.5 nM), and JAK3 (IC50 = 322 nM). JAKs, or Janus-associated kinases, are tyrosine kinases found in the cytoplasm that are known to active the signaling of certain growth factor receptors and cytokines. |
| 别名 | (betaR)-beta-环戊基-4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-丙腈;INCB 018424;INCB018424;INCB-018424;(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile |
鲁索替尼
Ruxolitinib (INCB018424) （订货以英文为准）
编号：R126338
CAS号：941678-49-5
分子式：C17H18N6
分子量：306.37
| 产品名称 | Ruxolitinib (INCB018424) |
| 中文名称 | 鲁索替尼 |
| CAS号 | 941678-49-5 |
| 分子式（M.F.） | C17H18N6 |
| 分子量（M.W.） | 306.37 |
| 储存条件 | -20°C储存 |
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