盐酸伊达比星

Idarubicin HCl (订货以英文为准)

编号:I129863
CAS号:57852-57-0
分子式:C26H27NO9.HCL
分子量:533.95
货号 品牌 包装 目录价 您的价格 库存 数量 购买
I129863-5mg 阿拉丁 5mg ¥498.90
I129863-50mg 阿拉丁 50mg ¥2471.90
I129863-10mg 阿拉丁 10mg ¥896.90
I129863-1mg 阿拉丁 1mg ¥140.90
产品名称 Idarubicin HCl
中文名称 盐酸伊达比星
CAS号 57852-57-0
分子式(M.F.) C26H27NO9.HCL
分子量(M.W.) 533.95
储存条件 -20°C储存
溶解性DMSO 100 mg/mL (187.28 mM);Water 7 mg/mL heating (13.1 mM);Ethanol <1 mg/mL (<1 mM)
存贮条件储存温度-20°C
应用An apoptosis inducer.
产品介绍Idarubicin HCl是Idarubicin的盐酸盐形式,是蒽环类抗生素,抑制DNA拓扑异构酶II (topo II),作用于MCF-7细胞,IC50为3.3 ng/mL。
备注Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL.
生化机理Idarubicin Hydrochloride is the hydrochloride salt preparation of Idarubicin (IDA), an anthracycline and an analog of daunorubicin. IDA is rapidly metabolized to its 13-dihydroderivative (Idarubicinol) which is more stable than the parent form. This compound has been reported to trigger apoptotic cell death via enhancement of Fas and caspase-3/caspase-7 expression. In experiments, where cells were exposed to IDA, reactive oxygen species (ROS) were produced which induced DNA strand breaks and prevented DNA polymerase reaction. Idarubicin Hydrochloride is an inhibitor of Topo II α. Idarubicin Hydrochloride is also a substrate of CYP2D6 and CYP2C9.
别名盐酸依达比星; 去甲氧基柔红霉素盐酸盐;Idamycin;Zavedos;4-demethoxydaunorubicin;Idamycin;Zavedos;4-demethoxydaunorubicin;(7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione hydrochloride
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