溶解性 | DMSO 103 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
存贮条件 | 储存温度-20°C |
产品介绍 | MLN9708 immediately hydrolyzed to MLN2238, the biologically active form, on exposure to aqueous solutions or plasma. MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM. |
备注 | MLN9708 immediately hydrolyzed to MLN2238, the biologically active form, on exposure to aqueous solutions or plasma. MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM |
生化机理 | MLN9708 immediately hydrolyzed to MLN2238, which is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the 20S proteasome with an IC50 value of 3.4 nM (Ki = 0.93 nM). |
别名 | 4-羧基-2-[(1R)-1-[[2-[(2,5-二氯苯甲酰基)氨基]乙酰基]氨基]-3-甲基丁基]-6-氧代-1,3,2-二氧硼杂环己-4-乙酸; MLN 9708; MLN-9708;Ixazomib; MLN 9708; MLN-9708;4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid |
柠檬酸伊沙佐米(MLN9708)
MLN9708 (订货以英文为准)
编号:M129243
CAS号:1201902-80-8
分子式:C20H23BCL2N2O9
分子量:517.12
产品名称 | MLN9708 |
中文名称 | 柠檬酸伊沙佐米(MLN9708) |
CAS号 | 1201902-80-8 |
分子式(M.F.) | C20H23BCL2N2O9 |
分子量(M.W.) | 517.12 |
储存条件 | -20°C储存 |
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