GW9508,FFA 1受体激动剂

GW9508 (订货以英文为准)

编号:G126253
CAS号:885101-89-3
分子式:C22H21NO3
分子量:347.41
货号 品牌 包装 目录价 您的价格 库存 数量 购买
G126253-50mg 阿拉丁 50mg ¥1237.90
G126253-10mg 阿拉丁 10mg ¥499.90
G126253-250mg 阿拉丁 250mg ¥2811.90
产品名称 GW9508
中文名称 GW9508,FFA 1受体激动剂
CAS号 885101-89-3
MDL编码 MFCD09753282
分子式(M.F.) C22H21NO3
分子量(M.W.) 347.41
储存条件 2-8°C储存
溶解性Soluble in ethanol (100 mM), DMSO (40 mg/ml), DMF (~15 mg/ml), and Ethanol : PBS (1:1) (~0.5 mg/ml)
存贮条件储存温度2-8°C
应用An aminophenylpropanoate agonist at the GRP40/FFA1 receptor.
产品介绍GW9508是一种有效的,选择性FFA1(GPR40)激动剂,pEC50为7.32,比作用于GPR120选择性高100倍,以葡萄糖敏感性方式刺激胰岛素的分泌。
备注GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.
生化机理GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ~50 nM) with reduced activity towards family members GRP120 (EC50 ~3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors. GW 9508 has been shown to induce GPR40-dependent Ca2+ mobilization in HEK 293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells.
别名4-[[(3-苯氧基苯基)甲基]氨基]苯丙酸;GW 9508;GW-9508;3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid; GPR40 Agonist;4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid
Merck Index3708
标识符号https://www.aladdin-e.com/images/ghs/ghs08.jpg
信号词Danger
危害声明H350,H360
警示性声明P201,P308+P313
个人防护设备Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
RTECSKG8575000
WGK德国3
风险声明 (欧洲)45,60,61
安全声明(欧洲)53,45
危害码(欧洲)T
搜索质检报告(COA)
搜索MSDS
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